SRP2137
FXR, ligand binding domain (222-472), GST tagged human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sinônimo(s):
FXR, NR1H4, farnesol receptor HRR-1, retinoid receptor
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10 μG
R$ 2.810,00
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10 μG
R$ 2.810,00
About This Item
Código UNSPSC:
12352200
NACRES:
NA.26
fonte biológica
human
recombinante
expressed in E. coli
Ensaio
≥70% (SDS-PAGE)
Formulário
frozen liquid
peso molecular
~56.3 kDa
embalagem
pkg of 10 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
concentração
400 μg/mL
cor
colorless to clear
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... HRR-1(9971)
Ações bioquímicas/fisiológicas
Farnesoid-X-activated receptor (FXR) was originally identified and cloned in rat as an orphan nuclear hormone receptor based on hybridization with a degenerate oligonucleotide designed from the highly conserved nuclear hormone receptor DNA binding domain. FXR functions as a heterodimer with RXR and binds to sequence elements in the promoters of target genes. The FXR/RXR heterodimer binds with highest affinity to inverted repeats separated by 1 bp (IR-1) and with low affinity to direct repeats separated by 4 and 5 bp (DR-4 and DR-5). As is the case for other nuclear hormone receptors, FXR regulates target gene activity in response to ligand. While initial studies suggested that farnesol and retinoid metabolites were likely ligands for FXR, current data support the notion that FXR is a bile acid sensor that plays an integral role in bile acid synthesis and transport. In the small intestine, FXR regulates bile acid uptake through the upregulation of the ileal bile acid binding protein gene via binding to an upstream response element. The FXR/RXR heterodimer can be activated by the bile salt chenodeoxycholic acid (CDCA) and FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene (the bile salt export pump). In addition, FXR has been shown to inhibit the cholesterol 7-hydrolase gene (CYP7A1) transcription.
forma física
Clear and colorless frozen liquid solution
Nota de preparo
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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W Seol et al.
Molecular endocrinology (Baltimore, Md.), 9(1), 72-85 (1995-01-01)
We have used a yeast genetic system to isolate cDNAs encoding proteins that specifically interact with the ligand-binding domain of human retinoid X receptor-alpha (RXR alpha). A number encoded portions of two known RXR heterodimer partners, the retinoic acid receptor
B M Forman et al.
Cell, 81(5), 687-693 (1995-06-02)
Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that
A M Zavacki et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(15), 7909-7914 (1997-07-22)
Retinoids are crucial regulators of a wide variety of processes in both developing and adult animals. These effects are thought to be mediated by the retinoic acid (RA) receptors and the retinoid X receptors (RXRs). We have identified an additional
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