SRP2081
Retinoblastoma protein human
recombinant, expressed in insect cells, ≥70% (SDS-PAGE)
Sinônimo(s):
OSRC, RB, p105-Rb, pRb, pp110, retinoblastoma 1
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.26
Produtos recomendados
fonte biológica
human
recombinante
expressed in insect cells
Ensaio
≥70% (SDS-PAGE)
forma
frozen liquid
peso molecular
~107.5 kDa
embalagem
pkg of 5 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
concentração
400 μg/mL
cor
clear colorless
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... RB1(5925)
Descrição geral
The gene encoding retinoblastoma-associated protein (RB1) is a tumor suppressor gene localized on human chromosome 13q14.2.
Ações bioquímicas/fisiológicas
pRB, the product of retinoblastoma susceptibility gene RB-1, is one of the best-studied tumor suppressor gene products. At least two other pRB-related proteins, p107 and p130, have been identified and characterized. Mutations in RB-1 gene are often associated with the occurrence of various tumors. The activity of pRB is regulated through phosphorylation in a cell cycle-dependent manner. The hyperphosphorylated RB protein usually associates with the cell nucleus and binds transcription factors of the E2F family. pRB represses transcription of its target genes, such as cdc2, cyclin A, and oncogene c-Myc, c-Fos through the binding with E2F factors and thereby regulating cell proliferation.
forma física
Clear and colorless frozen liquid solution
Nota de preparo
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Thao T Le et al.
Chemical science, 11(17), 4467-4474 (2020-04-21)
Although RNA aptamers can show comparable or better specificity and affinity to antibodies and have the advantage of being able to access different live cell compartments, they are often much less stable in vivo. We report here the first aptamer
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma.
S H Friend et al.
Nature, 323(6089), 643-646 (1986-10-16)
The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that their effects can be observed when they are introduced into non-malignant cells. There is evidence for another class of oncogenes, in which tumour-predisposing mutations are recessive
Z Onadim et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(13), 6177-6181 (1992-07-01)
The retinoblastoma-predisposition gene, RB1, segregates as an autosomal dominant trait with high (90%) penetrance. Certain families, however, show an unusual low-penetrance phenotype with many individuals being unaffected, unilaterally affected, or with evidence of spontaneously regressed tumors. We have used single-strand
W H Lee et al.
Science (New York, N.Y.), 235(4794), 1394-1399 (1987-03-13)
Recent evidence indicates the existence of a genetic locus in chromosome region 13q14 that confers susceptibility to retinoblastoma, a cancer of the eye in children. A gene encoding a messenger RNA (mRNA) of 4.6 kilobases (kb), located in the proximity
Frequent deletions at 11q23 and 13q14 in B cell prolymphocytic leukemia (B-PLL).
Lens D
Leukemia, 14(3), 427-430 (2000)
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