SRP2034
Topo I (N1-197) (NTD) human
recombinant, expressed in insect cells, ≥85% (SDS-PAGE)
Sinônimo(s):
TOPI
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.26
fonte biológica
human
recombinante
expressed in insect cells
Ensaio
≥85% (SDS-PAGE)
forma
frozen liquid
peso molecular
~25.3 kDa
embalagem
pkg of 5 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
concentração
1000 μg/mL
cor
clear colorless
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... TOP1(7150)
Ações bioquímicas/fisiológicas
Human DNA topoisomerase I is the best studied of the DNA topoisomerase family. It catalyzes the relaxation of both positive and negative supercoils without the requirement of energy. In addition to DNA replication and transcriptional activation, DNA topoisomerase I also plays a major role in pre-mRNA splicing, cell cycle and other gene regulatory pathways during cell growth and development. The N-terminal 214 amino acids of topoisomerase I comprise a highly charged N-terminal domain (NTD) involved in protein-protein interactions with a number of cellular proteins, including SV40 T antigen, nucleolin, SR proteins, p53 and other transcription factors.
forma física
Clear and colorless frozen liquid solution
Nota de preparo
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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D Gai et al.
Journal of virology, 74(11), 5224-5232 (2000-05-09)
Topoisomerase I (topo I) is required for releasing torsional stress during simian virus 40 (SV40) DNA replication. Recently, it has been demonstrated that topo I participates in initiation of replication as well as in elongation. Although T antigen and topo
Yinghui Mao et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(3), 1235-1240 (2002-01-24)
The nonconserved, hydrophilic N-terminal domain of eukaryotic DNA topoisomerase I (topo I) is dispensable for catalytic activity in vitro but essential in vivo. There are at least five putative nuclear localization signals and a nucleolin-binding signal within the first 215
P Haluska et al.
Nucleic acids research, 26(7), 1841-1847 (1998-05-30)
We have attempted to identify human topoisomerase I-binding proteins in order to gain information regarding the cellular roles of this protein and the cytotoxic mechanisms of the anticancer drug camptothecin, which specifically targets topoisomerase I. In the course of this
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