SML2857

LHVS

≥98% (HPLC)

• Sinônimo(s): (S)-(E)-3-(4-Morpholine-carbonylleucyl)amino-5-phenyl-1-phenylsulfonyl-1-pentene, Morpholinurea-leucine-homophenylalanine-vinylsulfone-phenyl, Mu-Leu-Hph-VSPh, Mu-Leu-HphVSPh
• Fórmula empírica (Notação de Hill): C₂₈H₃₇N₃O₅S
• Número CAS: 170111-28-1
• Peso molecular: 527.68
• Número MDL: MFCD32201152
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(N[C@@H](CC(C)C)C(N[C@H](/C=C/S(=O)(C1=CC=CC=C1)=O)CCC2=CC=CC=C2)=O)N3CCOCC3
• chave InChI: YUMYYTORLYHUFW-MSKIIMLESA-N

Descrição

Ações bioquímicas/fisiológicas

Irreversible, potent and selective cathepsin S inhibitor in vitro and in vivo.

LHVS is an irreversible, potent and selective cathepsin S inhibitor (CatS Ki = 5.9 nM; CatO2/L/B Ki = 0.23/0.72/39 μM, Cruzain Ki = 0.22 μM) that targets CatS active site thiol for covalent modification via its vinyl sulfone moiety. LHVS is a useful tool for studyting CatS-mediated responses in cultures (typical dosing ranges: 25 nM to 10μM) and in animals in vivo, including CatS-induced itch in mice (30 mg/kg sc.), morphine-induced antinociceptive tolerance in rats (50 nmol/rat itrathetically) and mechanical hyperalgesia in nerve-injured rats (3-30 mg/kg sc.).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable