SML2699

SHMT inhibitor Hit 1

≥98% (HPLC)

• Sinônimo(s): 4,4′-[2,4-Pyrimidinediylbis(4,1-phenyleneimino)]bis[4-oxo-butanoic acid
• Fórmula empírica (Notação de Hill): C₂₄H₂₂N₄O₆
• Número CAS: 330638-43-2
• Peso molecular: 462.45
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O=C(NC1=CC=C(C2=NC=CC(C3=CC=C(C=C3)NC(CCC(O)=O)=O)=N2)C=C1)CCC(O)=O
• InChI: 1S/C24H22N4O6/c29-20(9-11-22(31)32)26-17-5-1-15(2-6-17)19-13-14-25-24(28-19)16-3-7-18(8-4-16)27-21(30)10-12-23(33)34/h1-8,13-14H,9-12H2,(H,26,29)(H,27,30)(H,31,32)(H,33,34)
• chave InChI: LZRQXDAEFLBXCL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Inhibition of serine/glycine synthesis by SHMT inhibitors can be an effective strategy to treat serine/glycine synthesis-dependent cancers.[1] Therefore, SHMT inhibitor can be a potential cancer drug target.[2] SHMT inhibitor Hit 1 may inhibit SHMT with an IC50 of 0.53 μM.[2]

SHMT inhibitor Hit 1 is a potent and specific inhibitor of serine hydroxymethyltransferase (SHMT). SHMT inhibitor Hit 1 potently inhibits SHMT1 and SHMT2 in rat liver homogenate.

potent and specific inhibitor of serine hydroxymethyltransferase (SHMT)

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable