SML2657

MP-A08

≥98% (HPLC)

• Sinônimo(s): 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide, NSC-122314
• Fórmula empírica (Notação de Hill): C₂₇H₂₅N₃O₄S₂
• Número CAS: 219832-49-2
• Peso molecular: 519.64
• Número MDL: MFCD01053753
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [S](=O)(=O)(Nc2c(cccc2)\N=C\c3c(cccc3)N[S](=O)(=O)c4ccc(cc4)C)c1ccc(cc1)C
• chave InChI: FLDBNMYJUMAXDQ-TURZUDJPSA-N

Descrição

Ações bioquímicas/fisiológicas

ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2 (SphK 1 and 2)

MP-A08 is a highly selective ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. It is more selective and acts by different mechanisms than other SK inhibitors. MP-A0 targets the ATP-binding pocket, rather than the sphingosine binding pocket, with Ki values of 6.9 and 27 μM, respectively. Also, both SKI-II and PF-543 are thought to act in part by targeting sphingosine kinase for proteasomal degradation, which is not the case with MP-A08. MP-A08 was found to suppress the growth of human lung tumor xenografts in mice, both inducing apoptosis and inhibiting angiogenesis.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable