SML2622

ABC1183

≥98% (HPLC)

• Sinônimo(s): 4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile, 4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-benzonitrile
• Fórmula empírica (Notação de Hill): C₁₈H₁₄N₄OS
• Número CAS: 1042735-18-1
• Peso molecular: 334.39
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NC1=C(C(C2=CC=C(C=C2)C#N)=O)SC(NC3=CC=C(C)C=C3)=N1
• InChI: 1S/C18H14N4OS/c1-11-2-8-14(9-3-11)21-18-22-17(20)16(24-18)15(23)13-6-4-12(10-19)5-7-13/h2-9H,20H2,1H3,(H,21,22)
• chave InChI: CUDLEXBIVZPJBU-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

ABC1183 is an orally active, potent and selective inhibitor of GSK3 α/β and CDK9, which induces G2/M cell cycle arrest and apoptosis in cancer cells. Apparently ABC1183 suppresses tumor growth and inflammation-driven gastrointestinal disease symptoms due to down regulation of TNFα and IL-6 pro-inflammatory cytokines. It does not exhibit organ or hematological toxicities.

an orally active, potent and selective inhibitor of GSK3 α/β and CDK9

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable