SML1215

Cuspin-1

≥98% (HPLC)

• Sinônimo(s): (5-Bromo-3-pyridinyl)(4-methylphenyl)methanone
• Fórmula empírica (Notação de Hill): C₁₃H₁₀BrNO
• Número CAS: 337932-29-3
• Peso molecular: 276.13
• Número MDL: MFCD00452965
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825725
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to beige
• solubilidade: DMSO: 5 mg/mL, clear (warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: CC(C=C1)=CC=C1C(C2=CC(Br)=CN=C2)=O
• InChI: 1S/C13H10BrNO/c1-9-2-4-10(5-3-9)13(16)11-6-12(14)8-15-7-11/h2-8H,1H3
• chave InChI: AJZRSLVRFSCCIL-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Cuspin-1 (Chemical Upregulator of SMN Protein-1) is an upregulator of the Survival of Motor Neuron protein (SMN), necessary for survival of motor neurons. SMN is decreased in the neurodegenerative disease Spinal Muscular Atrophy (SMA), an autosomal recessive disease caused by a genetic defect in the SMN1 gene. SMA is the second leading cause of neuromuscular disease, after Duchenne muscular dystrophy. Cuspin-1 increased SMN levels by 50-100% in SMA patient fibroblast cells accompanied by an increase in the phosphorylation of Erk, suggesting inbvolvement of the Ras-Raf-MEK cascade.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3