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SML0817

Sigma-Aldrich

Pivmecillinam

≥98% (HPLC)

Sinônimo(s):

Amdinocillin pivoxil

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10 MG
R$ 382,00
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10 MG
R$ 382,00
50 MG
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About This Item

Fórmula empírica (Notação de Hill):
C21H33N3O5S
Número CAS:
32886-97-8
Peso molecular:
439.57
Número CE:
251-276-6
Número MDL:
MFCD00865080
Código UNSPSC:
51111800
ID de substância PubChem:
329825603
NACRES:
NA.77

R$ 382,00

Previsão de entrega em14 de abril de 2025

Solicite uma grande encomenda

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

atividade óptica

[α]/D +215 to +245°, c = 1 in ethanol

cor

white to beige

solubilidade

DMSO: 5 mg/mL, clear (warmed)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC1(C)[C@H](C(OCOC(C(C)(C)C)=O)=O)N2C([C@](/N=C/N3CCCCCC3)([H])[C@@]2([H])S1)=O

InChI

1S/C21H33N3O5S/c1-20(2,3)19(27)29-13-28-18(26)15-21(4,5)30-17-14(16(25)24(15)17)22-12-23-10-8-6-7-9-11-23/h12,14-15,17H,6-11,13H2,1-5H3/b22-12+/t14-,15+,17-/m1/s1

chave InChI

NPGNOVNWUSPMDP-UTEPHESZSA-N

Aplicação

Pivmecillinam has been used to test its efficacy as a breast cancer stem cells (CSCs) targeting agent.[1]

Ações bioquímicas/fisiológicas

Pivmecillinam is a β-lactam antibiotic and a pivaloyl-containing pro-drug.[2] It belongs to the class of amidinopenicillin.[3] Pivmecillinam is an oral anti-microbial agent that can be considered for treating E. coli urinary tract infection (UTI).[4]
Pivmecillinam is a gram negative antibiotic, and inhibitor of penicillin-binding protein 2 (PBP2).
Pivmecillinam is a gram negative antibiotic, and inhibitor of penicillin-binding protein 2 (PBP2). Pivmecillinam has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000407744
0000407742
0000407744
0000407742
0000214537

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Soichi Arakawa et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 13(5), 279-284 (2007-11-06)
We aimed to reveal the usefulness of and problematic points with the Criteria for evaluation of clinical efficacy of antimicrobial agents on urinary tract infection (draft fourth edition) proposed by the UTI Subcommittee of the Clinical Evaluation Guidelines Committee, Japan
Sven A Ferry et al.
Scandinavian journal of primary health care, 25(1), 49-57 (2007-03-14)
To analyse associations between symptoms and bacteriuria in uncomplicated lower urinary tract infection in women (LUTIW) and to evaluate outcome of therapy with three different regimens of pivmecillinam or placebo. Prospective, multicentre, randomized, double-blind, and placebo-controlled therapy study. Symptoms registered
Asa Sullivan et al.
Antimicrobial agents and chemotherapy, 49(1), 170-175 (2004-12-24)
The knowledge of the effects of antimicrobial agents on the normal vaginal microflora is limited. The objective of the present study was to study the ecological impact of pivmecillinam on the normal vaginal microflora. In 20 healthy women, the estimated
Maria Loose et al.
Antibiotics (Basel, Switzerland), 9(6) (2020-07-08)
Given the increasing antimicrobial resistance in urinary tract infections (UTI), alternative strategies need to be investigated. Determination of minimal inhibitory and bactericidal concentrations of essential oils from cajeput, lemongrass, tea tree, and thyme in artificial urine, revealed bactericidal activity of
Karen Ejrnaes et al.
Journal of clinical microbiology, 44(5), 1776-1781 (2006-05-05)
The primary infecting Escherichia coli strains from 156 women with community-acquired uncomplicated urinary tract infection (UTI) randomized to pivmecillinam or placebo and the E. coli strains causing UTI at two follow-up visits were typed using pulsed-field gel electrophoresis (PFGE). In
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