SML0668

Calhex 231 hydrochloride

≥98% (HPLC)

• Sinônimo(s): 4-Chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-benzamide hydrochloride
• Fórmula empírica (Notação de Hill): C₂₅H₂₇ClN₂O · HCl
• Número CAS: 652973-93-8
• Peso molecular: 443.41
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to beige
• solubilidade: DMSO: 15 mg/mL, clear
• temperatura de armazenamento: −20°C

Descrição

Aplicação

Calhex 231 hydrochloride has been used:

• as a calcium-sensing receptor (CaSR) antagonist: to test its impact on hearing in rats[1]
• to test its effect on blood pressure levels spontaneous hypertensive rats (SHRs)[2]
• to test its effect on acoustic response bias in zebrafish[3]
• in Caco-2 cells to test its effect on, overexpression of fibroblast growth factor-23 (FGF-23 )[4]

Ações bioquímicas/fisiológicas

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR.

Calhex 231 is a negative allosteric modulator of the calcium sensing receptor CaSR. Calhex 231 blocks calcium-induced accumulation of inositol phosphate with an IC₅₀ of 0.36 μM.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable