MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V.
MBCQ is selective inhibitor of cGMP-specific phosphodiesterase PDE V; IC50=19 nM.
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The Journal of clinical investigation, 129(6), 2318-2332 (2019-03-22)
Mice selectively expressing PPARγ dominant negative mutation in vascular smooth muscle exhibit RhoBTB1-deficiency and hypertension. Our rationale was to employ genetic complementation to uncover the mechanism of action of RhoBTB1 in vascular smooth muscle. Inducible smooth muscle-specific restoration of RhoBTB1
American journal of physiology. Cell physiology, 309(5), C332-C347 (2015-06-26)
The potent trypanolytic properties of human apolipoprotein L1 (APOL1) can be neutralized by the trypanosome variant surface antigen gene product known as serum resistance-associated protein. However, two common APOL1 haplotypes present uniquely in individuals of West African ancestry each encode
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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