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SML0261

Sigma-Aldrich

SC66

≥98% (HPLC)

Sinônimo(s):

(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone

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About This Item

Fórmula empírica (Notação de Hill):
C18H16N2O
Número CAS:
871361-88-5
Peso molecular:
276.33
Número MDL:
MFCD05025493
Código UNSPSC:
12352200
ID de substância PubChem:
329825269

Ensaio

≥98% (HPLC)

forma

powder

cor

faintly yellow to dark yellow

solubilidade

DMSO: ≥5 mg/mL (warmed)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1\C(CCC\C1=C/c2ccncc2)=C\c3ccncc3

InChI

1S/C18H16N2O/c21-18-16(12-14-4-8-19-9-5-14)2-1-3-17(18)13-15-6-10-20-11-7-15/h4-13H,1-3H2/b16-12+,17-13+

chave InChI

CYVVJSKZRBZHAV-UNZYHPAISA-N

Ações bioquímicas/fisiológicas

SC66 is an allosteric inhibitor of Akt that prevents binding of PIP3 to the PH domain. The compound prevents activation of Akt by PIP3, and also facilitates ubiquination and degradation of Akt. SC66 inhibition is maintained against a cancer relevant Akt mutation (E17K) that is resistant to the actions of PIP3K inhibitors. SC66 is active in vivo, and significantly inhibits the ability of HEK293T cells to form colonies in soft agar and tumor growth in nude mice.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Rong Chen et al.
Oxidative medicine and cellular longevity, 2020, 6954764-6954764 (2020-04-08)
Ischemic postconditioning (IPO) has a strong protective effect against intestinal ischemia-reperfusion (IIR) injury that is partly related to autophagy. However, the precise mechanisms involved are unknown. C57BL/6J mice were subjected to unilateral IIR with or without IPO. After 45 min ischemia
Chao-Yu Loung et al.
Molecules (Basel, Switzerland), 24(18) (2019-09-22)
Many dietary flavonoids possess anti-cancer activities. Here, the effect of apple peel flavonoid fraction 4 (AF4) on the growth of triple-negative (MDA-MB-231, MDA-MB-468), estrogen receptor-positive (MCF-7), and HER2-positive (SKBR3) breast cancer cells was determined and compared with the effect of
Q Lu et al.
Cell death & disease, 6, e2005-e2005 (2015-12-04)
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced autophagy remains elusive. In
Yanan Kong et al.
Journal of cellular physiology, 234(11), 20801-20815 (2019-04-30)
In diabetes, the number of bone mesenchymal stem cells (MSCs) decreases and their differentiation is impaired. However, the exact mechanism is unclear. Patients with diabetes often experience sympathetic nerve injury. Norepinephrine (NE), a major mediator of the sympathetic nervous system
Camilla Olaisen et al.
Cellular signalling, 27(7), 1478-1487 (2015-03-24)
Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two known PCNA-interacting motifs, the
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