SML0007

Cevimeline hydrochloride hemihydrate

≥95% (HPLC, NMR)

• Sinônimo(s): AF-102B, SNI-2011
• Fórmula empírica (Notação de Hill): C₁₀H₁₇NOS · xHCl · yH₂O
• Número CAS: 153504-70-2
• Peso molecular: 199.31 (anhydrous free base basis)
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825084
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC, NMR)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to tan
• solubilidade: H₂O: ≥25 mg/mL
• originador: Daiichi-Sankyo
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6
• InChI: 1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1
• chave InChI: ZSTLCHCDLIUXJE-GMLJRNIPSA-N

Descrição

Aplicação

Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

Cevimeline is a muscarinic M1 and M3 receptor agonist.

Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.

Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca⁺² in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.[1][2]

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable