SMB00579

Tacalcitol

≥99% (HPLC)

• Sinônimo(s): (1α,3β,5Z,7E,24R)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol, 1α,24R-dihydroxycholecalciferol, 1α,24R-dihydroxyvitamin D₃
• Fórmula empírica (Notação de Hill): C₂₇H₄₄O₃
• Número CAS: 57333-96-7
• Peso molecular: 416.64
• Número MDL: MFCD00866623
• Código UNSPSC: 12352205
• ID de substância PubChem: 329825068
• NACRES: NA.79

Propriedades

• fonte biológica: synthetic (organic)
• Nível de qualidade: 200
• Ensaio: ≥99% (HPLC)
• forma: powder
• técnica(s): HPLC: suitable
• cor: white to off-white
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: C[C@]1(CCC/2)[C@](CC[C@]1([H])[C@H](C)CC[C@@H](O)C(C)C)([H])C2=C\C=C3C[C@@H](O)C[C@H](O)C\3=C
• InChI: 1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1
• chave InChI: BJYLYJCXYAMOFT-RSFVBTMBSA-N

Descrição

Descrição geral

Tacalcitol is a synthetic vitamin D₃ analog. It is a vitamin D3 derivative, also known as 1α,24-dihydroxyvitamin D3.

Ações bioquímicas/fisiológicas

Tacalcitol is widely used in the treatment of dermatosis due to its ability to inhibit keratinocyte proliferation and induce cell differentiation. It also has anti-inflammatory activity and has been shown to reduce cutaneous inflammation via suppression of leukocyte infiltration in skin. Tacalcitol is topically used for the treatment of psoriasis and has also been found to be effective in the treatment of acquired perforating collagenosis (APC), a rare perforating dermatosis. Studies suggest that this compound has potential for the treatment of the hereditary disorder Hailey-Hailey Disease.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P301 + P330 + P331 + P310
• Classificações de perigo: Acute Tox. 1 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable