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SMB00313

Sigma-Aldrich

Gastrodin

≥98% (HPLC)

Sinônimo(s):

(2R,3S,4S,5R,6S)-2-Hydroxymethyl-6-(4-hydroxymethyl-phenoxy)-tetrahydro-pyran-3,4,5-triol, 4-β-D-glucopyranosyloxybenzyl alcohol, 4-Hydroxybenzyl alcohol 4-O-β-D-glucoside

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About This Item

Fórmula empírica (Notação de Hill):
C13H18O7
Número CAS:
Peso molecular:
286.28
Número MDL:
Código UNSPSC:
12352205
ID de substância PubChem:
NACRES:
NA.25

fonte biológica

plant (Gastrodia elata Blume)

Nível de qualidade

Ensaio

≥98% (HPLC)

forma

powder

aplicação(ões)

detection
metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O[C@@H]1[C@@H](CO)O[C@@H](OC2=CC=C(CO)C=C2)[C@H](O)[C@H]1O

InChI

1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1

chave InChI

PUQSUZTXKPLAPR-UJPOAAIJSA-N

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Descrição geral

Gastrodin, a phenolic glucoside, is the main active ingredient of the traditional Chinese medicinal compound Tianma. Gastrodin is an active component of Gastrodia elata Blume, a herb belonging to the Orchidaceae family.

Aplicação

Gastrodin has been used as a control to estimate the gastrodin content in the leaves, roots and stems of Anoectochilus formosanus Hayata.

Ações bioquímicas/fisiológicas

Gastrodin can penetrate through the blood-brain barrier and has been suggested to have neuroprotective effects against hypoxia. It is also known to reduce the immunoreactivity of gamma-aminobutyric acid shunt enzymes in hippocampal tissues. Traditionally, gastrodin is also known to be effective in the treatment of headache, vertigo, dizziness and convulsive disorders. Along with anticonvulsant property, it also possesses antiepileptic, anxiolytic, anti-inflammatory and antiobesity action. Gastrodin is also helps in learning and memory stimulation.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson?s disease model
Kumar H, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2013 (2013)
Yu Xing et al.
The international journal of biochemistry & cell biology, 109, 8-16 (2019-01-27)
The in vivo protective role of gastrodin (GSTD) in myocardial infarction (MI) has been reported. However, the underlying mechanism remains unclear. Herein, we aimed to explore the effects of GSTD on hypoxia-injured H9c2 cells as well as the downstream microRNAs
Tianyuan Ye et al.
International journal of molecular sciences, 19(12) (2018-12-14)
Patients with diabetes mellitus (DM) suffer more risks from diabetic encephalopathy such as cognitive dysfunction and depressive-like behaviors. Numerous studies show that ER (endoplasmic reticulum) stress and inflammation play important roles in the development of diabetic encephalopathy. Gastrodin (Gas), one
Enhanced Agronomic Traits and Medicinal Constituents of Autotetraploids in Anoectochilus formosanus Hayata, a Top-Grade Medicinal Orchid
Chung HH, et al.
Molecules (Basel), 22(11), 1907-1907 (2017)
Man Jiao et al.
Chemosphere, 226, 678-686 (2019-04-09)
The ubiquitous environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been shown to trigger neurotoxicity. In this study, we investigated the protective effects of gastrodin on TCDD-induced neurotoxicity and the underlying molecular mechanisms. The results show that gastrodin decreased cell viability, tumor necrosis

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