SAB5702340

Anti-Thyroglobulin Antibody, clone 3I10H1, Rabbit Monoclonal

• Sinônimo(s): AITD3, TGN
• Código UNSPSC: 12352203
• NACRES: NA.46

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• Materiais: colorless
• clone: 3I10H1, monoclonal
• forma: liquid
• reatividade de espécies: human, rat, rat
• concentração: 0.70 mg/mL
• técnica(s): immunofluorescence: 1:50 - 1:200; immunohistochemistry: 1:50 - 1:200
• cor: colorless
• Isotipo: IgG
• sequência de imunogênio: STLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKSRTSGLLSSWKQARSQENPSP
• nº de adesão UniProt: P01266
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TG(7038)

Descrição

Descrição geral

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

Imunogênio

A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Thyroglobulin (P01266).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Aplicação

IHC, IF/ICC

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1