SAB5702243

Anti-FGL1 Antibody, clone 5M3E6, Rabbit Monoclonal

• Sinônimo(s): FGL1,HFREP1,HP-041,LFIRE-1,LFIRE1
• Código UNSPSC: 12352203
• NACRES: NA.46

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• Materiais: colorless
• clone: 5M3E6, monoclonal
• forma: liquid
• peso molecular: 35 kDa
• reatividade de espécies: human
• concentração: 1.0mg/mL
• técnica(s): western blot: 1:500 - 1:1000
• cor: colorless
• Isotipo: IgG
• nº de adesão UniProt: Q08830
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... FGL1(2267)

Descrição

Descrição geral

Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy

Imunogênio

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Recombinant protein of human FGL-1 Full length.

Aplicação

WB

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1