SAB5700388

Anti-Phospho-HER2/ERBB2-Y1221/1222 antibody produced in rabbit

• Sinônimo(s): CD340, ERBB2, ErbB2, HER-2, HER-2/neu, HER2, HER2/ErbB2, MLN 19, MLN19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
• Código UNSPSC: 12352203
• NACRES: NA.43

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 134; 136; 137; 62; 70; 97
• reatividade de espécies: human
• concentração: 5.8 mg/ml
• técnica(s): western blot: 1:500-1:1000
• nº de adesão UniProt: P04626
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr1221/pTyr1222)
• Informações sobre genes: human ... ERBB2(2064)

Descrição

Descrição geral

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Imunogênio

A synthetic phosphorylated peptide around Y1221 & Y1222 of human HER2/ERBB2 (NP_004439.2).

forma física

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Armazenamento e estabilidade

Store at -20℃. Avoid freeze / thaw cycles.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable