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COO/COA

SAB5300353

Monoclonal Anti-CASP8 antibody produced in mouse

Name: Monoclonal Anti-CASP8 antibody produced in mouse
Brand: SIGMA

clone 1H11, ascites fluid

Sinônimo(s):

ALPS2B, CAP4, FLICE, MACH, MCH5

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About This Item

Código UNSPSC:

12352203

NACRES:

NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

1H11, monoclonal

peso molecular

26 kDa

reatividade de espécies

human, mouse, rat, monkey

técnica(s)

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

Isotipo

IgG1

nº de adesão NCBI

NM_001080124

nº de adesão UniProt

Q14790

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... CASP8(841)

Imunogênio

Purified recombinant fragment of human CASP8 expressed in E.coli.
Mouse monoclonal antibody raised against CASP8

forma física

Ascitic fluid containing 0.03% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.

Changyou Li et al.

Molecular oncology, 8(7), 1220-1230 (2014-05-13)

Little is known regarding molecular markers in head and neck squamous cell carcinoma (HNSCC) that predict responsiveness to different therapeutic regimens or predict HNSCC progression. Mutations in procaspase-8 occur in 9% of HNSCC primary tumors, but the functional consequences of

Ultrasound-targeted microbubble destruction combined with dual targeting of HSP72 and HSC70 inhibits HSP90 function and induces extensive tumor-speciﬁc apoptosis.

Hanghui Wang et al.

International journal of oncology, 45(1), 157-164 (2014-04-17)

The specific and efficient delivery of small interfering RNA (siRNA) into cancer cells in vivo remains a major obstacle. In this study, we investigated whether ultrasound-targeted microbubble destruction (UTMD) combined with dual targeting of HSP72 and HSC70 in prostate cancer cell

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage.

Wei Zuo et al.

Neuropharmacology, 86, 103-115 (2014-07-16)

Mitochondria dysfunction is implicated in diverse conditions, including metabolic and neurodegenerative disorders. Mitochondrial dynamics has attracted increasing attention as to its relationship with mitochondria autophagy, also known as mitophagy, which is critical for degradation of dysfunctional mitochondria maintaining mitochondrial homeostasis.

Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.

Ulrike Heinicke et al.

Cancer letters, 351(1), 50-58 (2014-05-13)

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood with a dismal prognosis, highlighting the need for novel treatment strategies. Here, we identify a novel synthetic lethal interaction between the histone deacetylase inhibitor (HDACI) SAHA and anticancer drugs in

Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.

Sireesha V Garimella et al.

Breast cancer research : BCR, 16(2), R41-R41 (2014-04-22)

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the downstream executioner caspases, caspase-3 and caspase-7 (caspase-3/7). Triple-negative breast cancer (TNBC) cell lines with

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