SAB4702130

Monoclonal Anti-CD22, purified produced in mouse

• Sinônimo(s): SIGLEC-2, SIGLEC2
• Código UNSPSC: 12352203

Propriedades

• conjugado: unconjugated
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: S-HCL-1, monoclonal
• forma: buffered aqueous solution
• reatividade de espécies: human
• concentração: 1 mg/ml
• técnica(s): flow cytometry: suitable
• Isotipo: IgG2bκ
• nº de adesão UniProt: P20273
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... CD22(933)

Descrição

Descrição geral

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Especificidade

The mouse monoclonal antibody S-HCL-1 (also known as S-HCL1) recognizes an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes.

Imunogênio

Whole hairy cell leukemia cells and membrane preparation

forma física

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

Nota de preparo

Purified by protein-A affinity chromatography.

Armazenamento e estabilidade

Store at 2-8°C. Do not freeze.

Outras notas

The antibody solution should be gently mixed before use.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable