SAB4702066

Monoclonal Anti-CD138 PE produced in mouse

• Sinônimo(s): SDC, SYND1, syndecan 1
• Código UNSPSC: 12352203

Propriedades

• conjugado: phycoerythrin (R-PE) conjugate
• Nível de qualidade: 100
• tipo de produto de anticorpo: primary antibodies
• clone: MI15, monoclonal
• forma: buffered aqueous solution
• reatividade de espécies: rat, ( Non-human primates), ( Human)
• técnica(s): flow cytometry: suitable
• Isotipo: IgG1κ
• nº de adesão UniProt: P18827
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SDC1(6382)

Descrição

Descrição geral

CD138 (syndecan 1) is a transmembrane proteoglycan that can bind a variety of cytokines and modulate their activity, as well as the activity of extracellular matrix components and influence many developmental processes. CD138 is expressed mainly in differentiating keratinocytes and is transiently upregulated in all layers of the epidermis upon tissue injury. It is also highly expressed on plasma cells and can be detected even on fibroblasts, vascular smooth muscle cells and endothelial cells. Up-regulation and down-regulation of CD138 on the cell surface often correlates with the gain of cancerous characteristics. Serum levels of the shedded soluble sCD138 are used as a prognostic factor of cancerogenesis.

Especificidade

The mouse monoclonal antibody MI15 recognizes an extracellular epitope of CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.

Imunogênio

A mixture of U266 and XG-1 human myeloma cell lines

forma física

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Nota de preparo

Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Armazenamento e estabilidade

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Outras notas

The antibody solution should be gently mixed before use.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable