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SAB4700192

Sigma-Aldrich

Monoclonal Anti-CD48 antibody produced in mouse

clone MEM-102, purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

Anti-BLAST-1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

MEM-102, monoclonal

forma

buffered aqueous solution

reatividade de espécies

nonhuman primates, human

concentração

1 mg/mL

técnica(s)

flow cytometry: suitable

Isotipo

IgG1

nº de adesão NCBI

NM_001778.2

nº de adesão UniProt

P09326

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CD48(962)

Categorias relacionadas

Descrição geral

Cluster of differentiation 48 (CD48) molecule, also known as BLAST1, is encoded by the gene mapped to human chromosome 1q23.3. CD48 is a glycosyl-phosphatidyl-inositol (GPI)-anchored cell-surface protein of immunoglobulin superfamily. The encoded protein is expressed on various hematopoietic cells.
The antibody MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchored membrane protein (immunoglobulin supergene family) widely expressed on hematopoietic cells; it is negative on granulocytes, platelets and erythrocytes.

Imunogênio

Raji human Burkitt′s lymphoma cell line

Aplicação

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Ações bioquímicas/fisiológicas

Cluster of differentiation 48 (CD48) acts as an adhesion and co-stimulatory molecule and stimulates various effects in B and T lymphocytes, natural killer cells, mast cells and eosinophils. CD48 interacts with its ligand CD2 and other molecules and promotes rearrangement of signaling factors in lipid rafts, Lck-kinase activity and tyrosine phosphorylation.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Characterization of the Epstein-Barr Virus-Inducible Gene Encoding the Human Leukocyte Adhesion and Activation Antigen BLAST-1 (CD48)
Fisher RC and Thorley-Lawson DA
Molecular and Cellular Biology, 11, 1614-1623 (1991)
The genetic differences between gallbladder and bile duct cancer cell lines.
Saito S
Oncology Reports, 16, 949-956 (2006)
CD48: A co-stimulatory receptor of immunity.
Elishmereni M and Levi-Schaffer F
The International Journal of Biochemistry & Cell Biology, 43, 25-28 (2011)
Soichiro Saito et al.
Oncology reports, 16(5), 949-956 (2006-10-04)
Biliary tract cancers carry dismal prognoses. It is commonly understood that chromosomal aberrations in cancer cells have prognostic and therapeutic implications. However, in biliary tract cancers the genetic changes have not yet been sufficiently studied. The aim of this study

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