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SAB4502148

Sigma-Aldrich

Anti-PDGFR β antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

CD140b, PDGF-R-β, PDGFR, PDGFR-β, kinase PDGFR-β

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 123 kDa

reatividade de espécies

mouse, human, rat

concentração

~1 mg/mL

técnica(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

P09619

nº de adesão UniProt

P09619

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... PDGFRB(5159)

Descrição geral

PDGFRB (platelet-derived growth factor receptor β) is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer. It is located on human chromosome 5q32.

Imunogênio

The antiserum was produced against synthesized peptide derived from human PDGFR beta.

Immunogen Range: 991-1040

Ações bioquímicas/fisiológicas

PDGFRB (platelet-derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC).

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Massive thromboembolism owing to the left ventricular thrombus associated with the hypereosinophilic syndrome
Kim J S, et al.
The Korean journal of thoracic and cardiovascular surgery, 47(5), 478-478 (2014)
Hongmei Duan et al.
Neural regeneration research, 19(2), 409-415 (2023-07-25)
Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation, differentiation, migration, and survival, as well as angiogenesis, in the context of brain injury. However, whether bioactive materials can repair the damage caused by ischemic stroke
Jennifer J Johnston et al.
American journal of human genetics, 97(3), 465-474 (2015-08-19)
Penttinen syndrome is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal and dermal atrophy along with hypertrophic lesions that resemble scars, thin hair, proptosis, underdeveloped cheekbones, and marked acro-osteolysis. All individuals have been simplex cases. Exome
Michael Vanlandewijck et al.
PloS one, 10(11), e0143407-e0143407 (2015-11-26)
Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several of these mutations in vitro. All six analyzed PDGFB mutations

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