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SAB4500068

Sigma-Aldrich

Anti-p27 KIP1 antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

CDKN1B, CDN1B, Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, KIP1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 22 kDa

reatividade de espécies

rat, mouse, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CDKN1B(1027)

Descrição geral

Anti-p27 KIP1 Antibody detects endogenous levels of total p27 KIP1 protein.
Cyclin-dependent kinase inhibitor 1B (CDKN1B or p27 KIP1) is a member of CDK inhibitor (CKI). The CDKN1B gene is mapped to human chromosome 12p13.1. The prime domains in CDKN1B include the nuclear export signal (NES) and the nuclear localization signal (NLS) and the CDK binding domain.

Imunogênio

The antiserum was produced against synthesized peptide derived from human p27 Kip1.

Immunogen Range: 1-50

Aplicação

Anti-p27 KIP1 antibody produced in rabbit has been used in western blotting (1:500).

Ações bioquímicas/fisiológicas

Cyclin-dependent kinase inhibitor 1B (CDKN1B) negatively regulates cell cycle events by binding to cyclin-dependent kinase. It is a tumor suppressor gene correlated with the pathophysiology of tumors. Germline mutations in CDKN1B are implicated in multiple endocrine neoplasia (MEN) syndrome and MEN-like syndrome (MENX). It is a potent biomarker in acute myeloid leukemia.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

Martina Kluth et al.
Oncotarget, 6(29), 27966-27979 (2015-08-22)
Deletion of 12p is a recurrent alteration in prostate cancer, but the prevalence and clinical consequences of this alteration have not been studied in detail. Dual labeling fluorescence in situ hybridization using probes for 12p13 (CDKN1B; p27) and centromere 12
Martina Cusan et al.
Frontiers in endocrinology, 9, 393-393 (2018-08-02)
The CDKN1B gene encodes for the p27Kip1 protein, firstly characterized as a cyclin dependent kinase (CDK)-inhibitor. Germline CDKN1B pathogenic variants have been described in hereditary tumors, such as multiple endocrine neoplasia (MEN)-like syndromes and familial prostate cancer. Despite its central
Gian Luca Rampioni Vinciguerra et al.
Cell division, 14, 2-2 (2019-04-13)
The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control of other cellular processes, including the regulation of cytoskeleton dynamics. Notably, these two functions involve distinct protein domains, residing in the
R McKay
Current opinion in neurobiology, 2(5), 582-585 (1992-10-01)
Several recent experiments have shown that immortal neural and muscle cells retain the specific temporal and spatial properties of their precursor cells in the animal. In addition, the immortal cells retain the ability to differentiate in vitro and, after transplantation
Ying Ding et al.
Molecular medicine (Cambridge, Mass.) (2015-04-01)
The process of islet transplantation for treating type 1 diabetes has been limited by the high level of graft failure that may be overcome by locally delivering trophic factors to enhance engraftment. Regenerating islet-derived protein 3 alpha (Reg3α) is a

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