SAB4301248

Anti-phospho-Pim-1 (pTyr³⁰⁹) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): EC 2.7.11.1, PIM-1, Proto-oncogene serine/threonine-protein kinase pim-1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 45 kDa
• reatividade de espécies: mouse, rat, human
• concentração: 1.0 mg/mL
• técnica(s): western blot: 1:500-1:1000 (Cell Lysate)
• Isotipo: IgG
• nº de adesão: NP_001230115.1
• nº de adesão UniProt: P11309
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr309)
• Informações sobre genes: human ... PIM1(5292)

Descrição

Descrição geral

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) is expressed at high levels in bone marrow, thymus, spleen, fetal liver, hippocampus, oral epithelium, and the prostate gland. PIM1 gene has five introns and six exons and is mapped to human chromosome 6p21.2.

Especificidade

The antibody detects endogenous levels of Pim-1 only when phosphorylated at tyrosine 309.

Imunogênio

Peptide sequence around phosphorylation site of tyrosine 309(H-R-Y(p)-H-G) derived from Human Pim-1.

Ações bioquímicas/fisiológicas

Pim-1 proto-oncogene, serine/threonine kinase (PIM1) modulates cell cycle progression, cellular division, differentiation, and apoptosis. It participates in genomic instability. PIM1 serves as an oncogenic survival factor. PIM1 gene is overexpressed in gastric carcinoma, squamous cell carcinoma, colorectal carcinoma, liver carcinoma, liposarcoma, and bladder cancer.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable