SAB4300246

Anti-phospho-SHC1 (pTyr⁴²⁷) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-FLJ26504 antibody produced in rabbit, Anti-SHC (Src homology 2 domain containing) transforming protein 1 antibody produced in rabbit, Anti-SHC antibody produced in rabbit, Anti-SHCA antibody produced in rabbit
• Número MDL: MFCD01634176
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: ~46 kDa; ~52 kDa
• reatividade de espécies: human
• concentração: 1 mg/mL
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• sequência de imunogênio: (P-S-YP-V-N
• nº de adesão NCBI: NP_001123512.1
• nº de adesão UniProt: P29353
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pTyr427)
• Informações sobre genes: human ... SHC1(6464)

Descrição

Imunogênio

Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N, according to the protein SHC1.

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Descrição-alvo

Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable