SAB4300115

Anti-phospho-CFL1 (pSer³) antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): Anti-CFL antibody produced in rabbit, Anti-cofilin 1 (non-muscle) antibody produced in rabbit
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: ~19 kDa
• reatividade de espécies: rat, human, mouse
• concentração: 1 mg/mL
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• Isotipo: IgG
• sequência de imunogênio: (M-A-SP-G-V)
• nº de adesão NCBI: NP_005498.1
• nº de adesão UniProt: P23528
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: phosphorylation (pSer3)
• Informações sobre genes: human ... CFL1(1072)

Descrição

Descrição geral

The cofilin 1 (CFL1) gene is mapped to human chromosome 11q13.1. It has four exons. The CFL1 gene codes for a ubiquitously expressed, 18.5 kDa phosphoprotein.

Imunogênio

Peptide sequence around phosphorylation site of serine 3 (M-A-S(p)-G-V), according to the protein CFL1.

Aplicação

Anti-phospho-CFL1 (pSer3) antibody produced in rabbit is used in Western Blotting.

Ações bioquímicas/fisiológicas

Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It facilitates cytokinesis, cell motility and morphogenesis. CFL1 is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the protein is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, its abnormal expression leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by synucleins (Syns).

Características e benefícios

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Descrição-alvo

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable