SAB4200828

Anti-Pseudomonas Exotoxin A-Peroxidase antibody produced in rabbit

IgG fraction of antiserum

• Sinônimo(s): ETA, NAD(+)--diphthamide ADP-ribosyltransferase, PE
• Código UNSPSC: 12352203

Propriedades

• fonte biológica: rabbit
• conjugado: peroxidase conjugate
• forma do anticorpo: IgG fraction of antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• descrição: Research area: Microbiome
• Formulário: lyophilized powder
• reatividade de espécies: Pseudomonas aeruginosa
• concentração: ~4 mg/mL
• técnica(s): direct ELISA: 1:10,000-1:20,000 (is recommended using 1 μg/ml Pseudomonas Exotoxin A for coating.)
• nº de adesão UniProt: P11439
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: Pseudomonas aeruginosa PAO1 ... toxA(877850)

Descrição

Descrição geral

Pseudomonas aeruginosa is a Gram negative bacterium that rarely cause diseases in humans but certain populations, such as cystic fibrosis (CF) or burn wounds patients, are prone to such infections.
Pseudomonas Exotoxin A (PE) is the most potent virulence factor secreted by P. aeruginosa, it is composed of three structural domains, N-terminal domain (I) responsible for the toxin binding to its host cell receptor, middle domain (II) has a role in toxin translocation across the membrane, and C-terminal domain (III) has ADP-ribosylation activity. PE is considered as a selective agent for the elimination of specific cell populations due to its toxin ADP-ribosylation activity resulting in irreversibly shut down of protein synthesis. To reduce the adverse effects of natural PE, Mutated PE was used in several attempts to develop recombinant toxin-antibody or cytokines fusion fragments for therapeutic application including cancer immunotherapy.

Imunogênio

Purified Exotoxin A from Pseudomonas aeruginosa

Aplicação

The antibody may be used in various immunochemical techniques including ELISA.

forma física

Supplied as a lyophilized powder.

Outras notas

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable