SAB4200644
Monoclonal Anti-C10orf54 antibody produced in mouse
clone ORF.4, purified from hybridoma cell culture
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100 μL
R$ 2.005,00
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100 μL
R$ 2.005,00
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
ORF.4, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
concentração
~1 mg/mL
técnica(s)
flow cytometry: 10 μg/test using human platelets
immunohistochemistry: suitable
Isotipo
IgG1
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... C10orf54(64115)
Categorias relacionadas
Descrição geral
Monoclonal Anti-C10orf54 (mouse IgG1 isotype) is derived from the hybridoma OR.4 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide.C10orf54 (Chromosome 10 open reading frame 54) is also referred to as GI24, B7 member B7-H5, VISTA (V-domain Ig suppressor of T cell activation) and Dies1. It is a novel surface glycoprotein belonging to the B7 immunoglobulin superfamily. It consists of a single IgV domain with 3 additional cysteine residues and a cytoplasmic tail. It is expressed on mature myeloid APCs (antigen-presenting cells) including peritoneal macrophages, mature BMDC (bone marrow-derived dendritic cell), neutrophils and CD11c+ DCs, and to a lesser quantity in T cells and activated Treg cells.
Imunogênio
synthetic peptide corresponding to a sequence at the internal region of human C10orf54
Aplicação
Phosphotyrosine antibody inhibitor has been used in flow-cytometry and immunohistochemistry.
Ações bioquímicas/fisiológicas
Studies suggest that C10orf54 (Chromosome 10 open reading frame 54) functions as a co-inhibitory ligand and restricts the mechanism of T cell proliferation and cytokine production. It was also suggested that C10orf 54 acts as a positive regulator as well as a substrate of MT1-MMP (trans-membrane type 1-matrix metalloproteinase) during tumor growth of collagen matrix, which regulates invasive growth.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Keunok Jung et al.
Immune network, 13(5), 184-193 (2013-11-08)
Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T
Li Wang et al.
The Journal of experimental medicine, 208(3), 577-592 (2011-03-09)
The immunoglobulin (Ig) superfamily consists of many critical immune regulators, including the B7 family ligands and receptors. In this study, we identify a novel and structurally distinct Ig superfamily inhibitory ligand, whose extracellular domain bears homology to the B7 family
Moustafa A Sakr et al.
Cancer science, 101(11), 2368-2374 (2010-07-30)
GI24, an immunoglobulin superfamily member, has been cloned from a placenta cDNA library as a gene product that promoted activation of matrix metalloproteinase (MMP)-2 mediated by membrane type (MT) 1-MMP. Co-expression of GI24 with MT1-MMP in HEK293T cells increased the
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