SAB4200630

Monoclonal Anti-SFRP1 antibody produced in mouse

clone FRP148, purified from hybridoma cell culture

• Sinônimo(s): Anti-FRP, Anti-FRP-1, Anti-FrzA, Anti-Secreted apoptosis-related protein 2 (SARP2), Anti-secreted frizzled-related protein 1
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: FRP148, monoclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~35 kDa
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): flow cytometry: 10-20 μg/test using using WI-38 cells.; immunoblotting: 0.025-0.05 μg/mL using using whole extracts of WI-38 cells.
• Isotipo: IgG2a
• nº de adesão UniProt: Q8N474
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SFRP1(6422)

Descrição

Descrição geral

The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.

Imunogênio

synthetic peptide corresponding to a sequence at the N-terminal region of human SFRP1.

Ações bioquímicas/fisiológicas

Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable