SAB4200623

Anti-C9orf72 antibody produced in rabbit

affinity isolated antibody

• Sinônimo(s): 3110043O21Rik, AI840585, ALSFTD, C9orf72, FLJ11109, FTDALS, RGD1359108, RP23-307M2.1, zgc:100846
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• Formulário: buffered aqueous solution
• peso molecular: ~55 kDa
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): immunoblotting: 0.3-0.6 μg/mL using whole extracts of T98G cells; immunocytochemistry: 4-6 μg/mL using SH-SY-5Y cells; immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon sections
• nº de adesão UniProt: Q96LT7
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... C9orf72(203228)

Descrição

Descrição geral

C9orf72 (chromosome 9 open reading frame 72) is a DENN domain containing protein. It is expressed in neuronal cell lines. It has been reported that C9orf72 colocalizes with Rab proteins, which indicates its role in autophagy and endocytic transport pathways.

Chromosome 9 open reading frame 72 (C9orf72) gene is mapped to human chromosome 9p21.

Especificidade

Anti-C9orf72 recognizes human C9orf72.

Imunogênio

synthetic peptide corresponding to the N-terminal region of human C9orf72

Aplicação

Anti-C9orf72 antibody produced in rabbit may be used in:

• immunoblotting
• immunocytochemistry
• immunohistochemistry

Ações bioquímicas/fisiológicas

C9orf72 (chromosome 9 open reading frame 72) maintains a physical interaction with Rab proteins during autophagy, cellular trafficking and protein degradation. The cellular activities of the protein are not well defined. It has been reported that mutations of C9orf72 gene are associated with amyotrophic lateral sclerosis (ALS) with degeneration of upper and lower motor neurons in the brain, brainstem and spinal cord, leading to progressive paralysis and frontotemporal dementia.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Armazenamento e estabilidade

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): nwg
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable