SAB4200358

Anti-PLAUR antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-CD87, Anti-U-PAR, Anti-UPAR, Anti-URKR, Anti-Urokinase receptor, Anti-plasminogen activator
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen 45/50 kDa
• reatividade de espécies: human
• concentração: ~1.0 mg/mL
• técnica(s): indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells over-expressing human PLAUR.
• nº de adesão UniProt: Q03405
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PLAUR(5329)

Descrição

Descrição geral

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR), a member of Ly6/ neurotoxin receptor family, is a heavily glycosylated glycosyl-phosphatidylinositol (GPI)-anchored cell-surface receptor. It is comprised of serine protease uPA, specific inhibitors (plasminogen activator inhibitors 1 and 2) and three internally disulfide-bonded domains (D1, D2 and D3).

Imunogênio

peptide corresponding to a sequence at the C-terminus of human PLAUR, conjugated to KLH. The corresponding sequence is identical in monkey PLAUR.

Aplicação

Anti-PLAUR antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Ações bioquímicas/fisiológicas

Plasminogen activator urokinase receptor (PLAUR)/ urokinase plasminogen activator receptor (uPAR) acts as a receptor for urokinase plasminogen activator (uPA). It localizes and promotes plasmin formation. uPAR influences many normal and pathological processes related to cell surface plasminogen activation, degradation of the extracellular matrix, cell migration, leukocyte adhesion, chemotaxis and signal transduction during leukocyte recruitment from the circulation to extravascular sites of inflammation. It is implicated as an anti-cancer target. uPAR is involved in epilepsy, language, cognition, communication and central nervous system disorders.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable