SAB4200282

Anti-TRIM2 (C-terminal region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinônimo(s): Anti-Tripartite motif-containing protein 2, RNF86, Narf
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• reatividade de espécies: rat, human
• validação aprimorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentração: ~1.0 mg/mL
• técnica(s): immunoprecipitation (IP): 5-10 μg using rat spinal cord extracts (S1 fraction); western blot: 1.5-3.0 μg/mL using MCF7 cell lysates
• nº de adesão UniProt: Q9C040
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... TRIM2(23321) ; rat ... Trim2(361970)

Descrição

Descrição geral

Tripartite motif containing 2 (TRIM2) is an E3 ubiquitin ligase, encoded by the gene mapped to human chromosome 4q31.3. The encoded protein belongs to the TRIM– NCL-1, HT2A and Lin-41 (NHL) protein family. This 81kDa protein is characterized with an N-terminal really interesting new gene (RING) finger domain and a B-box domain, a middle coiled-coil domain and a C-terminal NHL domain.

Imunogênio

synthetic peptide corresponding to a sequence located near the C-terminus of human TRIM2, conjugated to KLH. The corresponding sequence is identical in mouse and rat TRIM2.

Ações bioquímicas/fisiológicas

Tripartite motif containing 2 (TRIM2) ubiquitinates neurofilament light chain, B-cell lymphoma 2 (Bcl-2)-interacting mediator and motor protein myosin V. ) It has a role in polarization of neurons and outgrowth of axons. Loss of function of the protein has been linked to early-onset axonal neuropathy.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable