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Key Documents

SAB4200030

Sigma-Aldrich

Anti-HOXD9 (Internal Region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-HOX4C, Anti-Homeobox D9, Anti-Hox-4.3

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen ~40 kDa

reatividade de espécies

human

embalagem

antibody small pack of 25 μL

concentração

~1.0 mg/mL

técnica(s)

immunoprecipitation (IP): 2.5-5 μg using lysates of HEK-293T cells over expressing human HOXD9
indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed HEK-293T cells over expressing human HOXD9
western blot: 1-2 μg/mL using lysates of HEK-293T cells over expressing human HOXD9

nº de adesão UniProt

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HOXD9(3235)
mouse ... Hoxd9(15438)
rat ... Hoxd9(688999)

Descrição geral

There are 39 homeobox (HOX) genes in vertebrates. They are divided into four clusters (HOXA−HOXD), located on different chromosomes (7p15, 17q21.2, 12q13 and 2q31). Each cluster contains 9−11 member genes encoding relatively small gene products containing a highly conserved 60-amino-acid region (the homeobox), with DNA-binding activity that contributes to their activity as transcription factors. The HOX genes are evolutionarily conserved.

Aplicação

Anti-HOXD9 (Internal Region) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Ações bioquímicas/fisiológicas

Homeobox (HOX) transcription factors control important development pathways involved embryo morphogenesis. HOX genes mainly participate in the formation of the body plan during embryonic development. Altered homeobox gene function or expression is implicated in the development of cancers such as leukemias or neoplasms of the breast, prostate, kidney, colon, skin, and brain. HOXD9 is involved in patterning of forelimb, axial skeleton and embryonic segmentation. It might promote cell migration, invasion and metastasis in hepatocellular carcinoma. HOXD9 was shown to be involved in the early stages of normal joint development and also in the pathologic process of arthritis.

forma física

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

HOXD9 promotes epithelial-mesenchymal transition and cancer metastasis by ZEB1 regulation in hepatocellular carcinoma
Lv X, et al.
Journal of Experimental & Clinical Cancer Research, 34(1), 133-133 (2015)
Role of HOX genes in stem cell differentiation and Cancer
Bhatlekar S, et al.
Stem Cells International, 2018(1), 107-113 (2018)
Histone acetylation regulates the expression of HoxD9 transcription factor in endothelial progenitor cells
Iordache F, et al.
Romanian Journal of Morphology and Embryology, 56(1), 107-113 (2015)
Expression of murine HOXD9 during embryonic joint patterning and in human T lymphotropic virus type I tax transgenic mice with arthropathy resembling rheumatoid arthritis.
Khoa ND, et al.
Arthritis and Rheumatism, 42(4), 686-696 (1999)

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