SAB3500661

Anti-VKORC1 antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• peso molecular: 18 kDa
• reatividade de espécies: mouse, human
• concentração: 1 mg/mL
• técnica(s): ELISA: suitable; western blot: suitable
• nº de adesão NCBI: NP_076869
• nº de adesão UniProt: Q9BQB6
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... VKORC1(79001)

Descrição

Descrição geral

Vitamin K epoxide reductase complex subunit 1 (VKORC1), also known as vitamin K clotting factor deficiency type 2 (VKCFD2), is an integral, 163-amino acid long transmembrane protein. It is encoded by the gene mapped to a 20Mb region on human chromosome 16p12–q21. VKORC1 is widely expressed in various tissues and organs.

Imunogênio

Antibody was raised against a 15 amino acid peptide near the amino terminus of human VKORC1.

Ações bioquímicas/fisiológicas

Vitamin K epoxide reductase complex subunit 1 (VKORC1) enzyme plays a vital role in vitamin K cycle. It catalyzes the conversion of inactive vitamin K to vitamin K hydroquinone, which is crucial for the post-translational γ-carboxylation of vitamin K–dependent clotting factors II (prothrombin), VII, IX, and X. VKORC1 acts as a key target for oral anticoagulants and is also involved in drug metabolism.{4} Genetic variation in the gene leads to warfarin resistance and multiple coagulation factor deficiency type 2.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Ligação

The action of this antibody can be blocked using blocking peptide SBP3500661.

forma física

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable