SAB3500428

Anti-DR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinônimo(s): Anti-TRAIL-R1
• Número MDL: MFCD01864349
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: IgG fraction of antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: predicted mol wt 56 kDa
• reatividade de espécies: human
• técnica(s): immunocytochemistry: suitable; immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• nº de adesão NCBI: AAC51226
• nº de adesão UniProt: O00220
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TNFRSF10A(8797)

Descrição

Descrição geral

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1), also known as DR4, is encoded by the gene mapped to human chromosome 8p21-22. It belongs to the TNFR superfamily of transmembrane proteins. TRAIL-R1 contains a cytoplasmic "death domain," which can activate the cell′s apoptotic machinery. TRAIL receptor-1/DR4 is activated by binding to either membrane anchored or soluble TRAIL/Apo2L.

Imunogênio

DR4 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR4 protein.

Aplicação

Anti-DR4 antibody produced in rabbit has been used in western blotting.

Ações bioquímicas/fisiológicas

Soluble tumor necrosis factor-related apoptosis-inducing ligand-receptor 1 (sTRAIL-R1) interacts with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and stimulates cell-death signaling pathway. Mutation of the sTRAIL-R1 gene is associated with the pathogenesis of non-Hodgkin′s lymphoma (NHL). In addition, variation of TRAIL-R1 also increases the risk of susceptibility to prostate cancer (PCa) in North Indian population.

Características e benefícios

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Ligação

The action of this antibody can be blocked using blocking peptide SBP3500428.

forma física

Supplied in PBS with 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable