SAB3500093

Anti-JMJD1A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-JHDM2A, Anti-JHMD2A, Anti-KDM3A, Anti-Lysine-specific demethylase 3A, Anti-TSGA
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: predicted mol wt 145 kDa
• reatividade de espécies: human, mouse, rat
• técnica(s): immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• nº de adesão NCBI: NP_060903
• nº de adesão UniProt: Q9Y4C1
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... KDM3A(55818)

Descrição

Descrição geral

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

Imunogênio

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

Ações bioquímicas/fisiológicas

Jumonji domain containing 1A protein (JMJD1A) is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of signal transducer and activator of transcription 3 (STAT3), a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells. Decreased JMJD1A expression is correlated with the differentiation of cultured mES cells following the removal of the cytokine leukemia inhibitory factor (LIF). These findings suggest that JMJD1A might be a signaling molecule having a role in maintaining pluripotency in embryonic stem cells.

Características e benefícios

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Ligação

The action of this antibody can be blocked using blocking peptide SBP3500093.

forma física

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable