Todas as fotos(2)

Key Documents

COO/COA

SAB2500703

Anti-NOVA1 antibody produced in goat

Name: Anti-NOVA1 antibody produced in goat
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-Neuro-oncological ventral antigen 1, Anti-Paraneoplastic Ri antigen, Anti-Ventral neuron-specific protein 1

Faça loginpara ver os preços organizacionais e de contrato

Todas as fotos(2)

About This Item

Número MDL:

MFCD03791921

Código UNSPSC:

12352203

NACRES:

NA.41

fonte biológica

goat

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

reatividade de espécies

human

técnica(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

nº de adesão UniProt

P51513

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NOVA1(4857)

Descrição geral

NOVA1 (Neuro-oncological ventral antigen 1) is a neuron-specific nuclear RNA-binding protein expressed in brain, specifically in the hippocampus, hypothalamus, cingulate cortex, and medial habenular nucleus.

Imunogênio

Peptide with sequence C-REMPQNVAKTEPVS from the internal region of the protein sequence according to NP_002506.2 ; NP_006480.2 ; NP_006482.1.

Aplicação

Anti-NOVA1 antibody produced in goat is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) and western blot analysis.

Ações bioquímicas/fisiológicas

NOVA1 (Neuro-oncological ventral antigen 1) is associated with several post-transcriptional regulation of RNA metabolism including RNA splicing, editing to transport, localization, and degradation. It may be involved in mediating neuronal responsiveness. It encodes a protein, which has homology with the RNA-binding protein hnRNP K, the yeast splicing protein MER1.Since, it has some homology with hnRNP K, it may influence the regulation of RNA splicing or metabolism in developing neurons. The importance of NOVA1 as prognostic marker has been reported in HCC (Hepatocellular carcinoma). Alteration in gene causes a disorder associated with breast cancer and motor dysfunction i.e. paraneoplastic opsoclonus myoclonus ataxia (POMA).

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Não está encontrando o produto certo?

Experimente o nosso Ferramenta de seleção de produtos.

Pictogramas

GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319

Declarações de precaução

P305 + P351 + P338

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.

R J Buckanovich et al.

Neuron, 11(4), 657-672 (1993-10-01)

Paraneoplastic opsoclonus-ataxia, a disorder of motor control, develops in breast or lung cancer patients who harbor an antibody (Ri) that recognizes their tumors and a nuclear neuronal protein of 55 kd. We have characterized a gene, Nova, encoding an antigen

The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo.

R J Buckanovich et al.

Molecular and cellular biology, 17(6), 3194-3201 (1997-06-01)

Nova-1, an autoantigen in paraneoplastic opsoclonus myoclonus ataxia (POMA), a disorder associated with breast cancer and motor dysfunction, is a neuron-specific nuclear RNA binding protein. We have identified in vivo Nova-1 RNA ligands by combining affinity-elution-based RNA selection with protein-RNA

High expression of neuro-oncological ventral antigen 1 correlates with poor prognosis in hepatocellular carcinoma.

Yi-An Zhang et al.

PloS one, 9(3), e90955-e90955 (2014-03-13)

Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with

Dynamic expression pattern of neuro-oncological ventral antigen 1 (Nova1) in the rat brain after focal cerebral ischemia/reperfusion insults.

Hualing Li et al.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 61(1), 45-54 (2012-10-09)

The present study aimed to evaluate the expression of neuro-oncological ventral antigen 1 (Nova1) in cerebral ischemia/reperfusion (I/R) insults by immunohistochemistry. The focal cerebral I/R model was induced by right middle cerebral artery occlusion (MCAO) for 120 min followed by

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica