SAB1408617
Anti-PFKFB1 antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
Sinônimo(s):
F6PK, HL2K, MGC116715, MGC116717, PFRX
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100 μG
R$ 4.090,00
R$ 4.090,00
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100 μG
R$ 4.090,00
About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
R$ 4.090,00
Check Cart for Availability
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen ~54.7 kDa
reatividade de espécies
human
técnica(s)
immunofluorescence: suitable
western blot: 1 μg/mL
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... PFKFB1(5207)
Categorias relacionadas
Descrição geral
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) is encoded by the gene mapped to human chromosome Xp11.21. The encoded protein is one among the four isoenzymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. PFKFB1 is expressed predominantly in liver.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. (provided by RefSeq)
Imunogênio
PFKFB1 (NP_002616.1, 1 a.a. ~ 471 a.a) full-length human protein.
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Aplicação
Anti-PFKFB1 antibody produced in rabbit has been used in western blotting.
Ações bioquímicas/fisiológicas
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate. It plays a vital role in regulation of both glycolysis and gluconeogenesis. PFKFB1 also facilitates cell growth and apoptosis.
forma física
Solution in phosphate buffered saline, pH 7.4
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 is essential for p53-null cancer cells.
Ros S, et al.
Oncogene, 36(23), 3287-3287 (2017)
Gene expression analysis of epidermolysis bullosa simplex with mottled pigmentation
Bchetnia M, et al.
Journal of Dermatological Science, 69(1), 80-82 (2013)
A pericentric inversion of chromosome X disrupting F8 and resulting in haemophilia A
Xin Y, et al.
Journal of Clinical Pathology (2017)
R S Batra et al.
Genomics, 40(2), 358-361 (1997-03-01)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. Previous studies assigned the gene for human liver PFK-2/FBPase-2 (HGMW-approved symbol PFKFB1) to the X chromosome; however, precise localization remained ambiguous, with the gene variously placed
S Ros et al.
Oncogene, 36(23), 3287-3299 (2017-01-17)
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of this enzyme. We found that
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