SAB1406267

Anti-PLSCR1 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Sinônimo(s): MMTRA1B
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: antigen ~35 kDa
• reatividade de espécies: human
• técnica(s): western blot: 1 μg/mL
• nº de adesão NCBI: NM_021105.1
• nº de adesão UniProt: O15162
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PLSCR1(5359)

Descrição

Descrição geral

Phospholipid scramblase 1 (PLSCR1) is a 35kDa calcium dependant phospholipid translocator. The gene is located on human chromosome 3q24. The protein is overexpressed in tumor cells.

Imunogênio

PLSCR1 (NP_066928.1, 1 a.a. ~ 318 a.a) full-length human protein.

Sequence
MDKQNSQMNASHPETNLPVGYPPQYPPTAFQGPPGYSGYPGPQVSYPPPPAGHSGPGPAGFPVPNQPVYNQPVYNQPVGAAGVPWMPAPQPPLNCPPGLEYLSQIDQILIHQQIELLEVLTGFETNNKYEIKNSFGQRVYFAAEDTDCCTRNCCGPSRPFTLRIIDNMGQEVITLERPLRCSSCCCPCCLQEIEIQAPPGVPIGYVIQTWHPCLPKFTIQNEKREDVLKISGPCVVCSCCGDVDFEIKSLDEQCVVGKISKHWTGILREAFTDADNFGIQFPLDLDVKMKAVMIGACFLIDFMFFESTGSQEQKSGVW

Ações bioquímicas/fisiológicas

Phospholipid scramblase 1 (PLSCR1) bidirectionally transfers lipids across the membranes. It negatively regulates autophagy in mantle cell lymphoma (MCL). This protein is known to scramble phospholipids in the plasma membrane and thereby, disrupt membrane asymmetry. It functions as a multifunctional signalling molecule. It also has nuclease activity. PLSCR1 plays a role in cell proliferation, differentiation, apoptosis, pathogenesis of cancers, particularly leukemia.

forma física

Solution in phosphate buffered saline, pH 7.4

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable