SAB1405511

Anti-BCL3 antibody produced in mouse

purified immunoglobulin, buffered aqueous solution

• Sinônimo(s): BCL4, D19S37
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: purified immunoglobulin
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~46.8 kDa
• reatividade de espécies: human
• técnica(s): indirect immunofluorescence: suitable; western blot: 1 μg/mL
• nº de adesão NCBI: NM_005178
• nº de adesão UniProt: P20749
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... BCL3(602)

Descrição

Descrição geral

B cell lymphoma 3 (BCL3), an oncogene, belongs to the inhibitor of the κ B (IκB) family. It is a nuclear protein with a transactivation domain. BCL3 gene is located on the human chromosome 19q13.

Imunogênio

BCL3 (NP_005169.1, 1 a.a. ~ 446 a.a) full-length human protein.

Sequence
MDEGPVDLRTRPKAAGLPGAALPLRKRPLRAPSPEPAAPRGAAGLVVPLDPLRGGCDLPAVPGPPHGLARPEALYYPGALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQGNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHGQTAAHLACEHRSPTCLRALLDSAAPGTLDLEARNYDGLTALHVAVNTECQETVQLLLERGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLPLVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSPESSSRLSSNGLLSASPSSSPSQSPPRDPPGFPMAPPNFFLPSPSPPAFLPFAGVLRGPGRPVPPSPAPGGS

Ações bioquímicas/fisiológicas

B cell lymphoma 3 (BCL3) serves as a transcription co-activator. It modulates cyclin D1 transcription in human breast epithelial cells and keratinocytes. BCL3 stabilizes cellular Myc (c-Myc) protein and stimulates tumorigenesis in colorectal cancer cells. It can prevent apoptosis in MCF7AZ breast cancer cells. BCL3 plays a key role in the transcription of cellular inhibitors of apoptosis proteins 1 and 2 (cIAP1 and cIAP2) genes. It might be a possible biomarker in triple-negative breast cancer (TNBC) patients with the basal-like (BL1) subtype.

forma física

Solution in phosphate buffered saline, pH 7.4

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable