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S9882

Sigma-Aldrich

Sulfachloropyridazine

Sinônimo(s):

4-Amino-N-(6-chloro-3-pyridazinyl)benzenesulfonamide, N1-(6-Chloro-3-pyridazinyl)sulfanilamide

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About This Item

Fórmula empírica (Notação de Hill):
C10H9ClN4O2S
Número CAS:
80-32-0
Peso molecular:
284.72
Beilstein:
261558
Número CE:
201-269-9
Número MDL:
MFCD00057371
Código UNSPSC:
51102829
ID de substância PubChem:
24899860
NACRES:
NA.85

Formulário

powder

cor

off-white to light yellow

solubilidade

0.5 M NaOH: soluble 50 mg/mL

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Modo de ação

DNA synthesis | interferes

cadeia de caracteres SMILES

Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2

InChI

1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

chave InChI

XOXHILFPRYWFOD-UHFFFAOYSA-N

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Aplicação

Sulfachloropyridazine is a sulfonamide antibiotic that is used to study kinetics, reaction pathways and toxicity evolution[1]. Sulfachloropyridazine has been used to treat acute urinary tract infections in pediatric patients[2].

Ações bioquímicas/fisiológicas

Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[3]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine[4].

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H317

Declarações de precaução

P280

Classificações de perigo

Skin Sens. 1

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
MKCC5271
SLBD3636V
070M1413
048K1249
045K0148

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Absorption and Excretion of Sulfachloropyridazine
Wilfred F. Jones, Jr, Mohsen Ziai, et al.
Exp. Biol. Med, 95, 642-645 (1957)
[Sulfachloropyridazine in the treatment of acute infections of the urinary tract in childhood].
R C PEDRINAZZI et al.
Minerva pediatrica, 12, 1342-1347 (1960-10-27)
Paul A Blackwell et al.
Chemosphere, 67(2), 292-299 (2007-01-06)
The environmental fate of the antibiotics sulfachloropyridazine and oxytetracycline was investigated in a sandy loam soil. Liquid pig manure was fortified with the compounds and then applied to soil plots to investigate leaching, dissipation and surface run-off under field conditions.
Paul Kay et al.
Environmental toxicology and chemistry, 23(5), 1136-1144 (2004-06-08)
The environment may be exposed to veterinary medicines administered to livestock through the application of organic fertilizers to land. For other groups of substances that are applied to agricultural land (e.g., pesticides), preferential flow in underdrained clay soils has been
Thomas L ter Laak et al.
Environmental toxicology and chemistry, 25(4), 904-911 (2006-04-25)
Antimicrobial agents are the most heavily used pharmaceuticals in intensive husbandry. Their usual discharge pathway is application to agricultural land as constituents of animal manure, which is used as fertilizer. Many of these compounds undergo pH-dependent speciation and, therefore, might
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