S8939

SGK1 (δ1-60, S422D), active human

recombinant, expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged), buffered aqueous solution

• Número MDL: MFCD03458482
• Código UNSPSC: 51111800
• NACRES: NA.32

Propriedades

• recombinante: expressed in baculovirus infected Sf9 cells (truncated human sequence (a.a. 1-60 deleted, S422D mutation)-histidine-tagged)
• Nível de qualidade: 200
• forma: buffered aqueous solution
• peso molecular: ~48 kDa by SDS-PAGE
• nº de adesão UniProt: O00141
• Condições de expedição: dry ice
• temperatura de armazenamento: −70°C
• Informações sobre genes: human ... SGK1(6446)

Descrição

Descrição geral

The serum- and glucocorticoid-regulated kinase (SGK1) is a member of the AGC kinase family and the gene encoding it is localized on human chromosome 6q23.

Ações bioquímicas/fisiológicas

The serum- and glucocorticoid-regulated kinase (SGK1) has a role in the hormonal regulation of ion channels and pumps. It has been associated with cancers. The protein modulates nitric oxide production by activating NO synthase. SGK1 protects cells from apoptosis and oxidative stress.

Kinase assays.

Definição da unidade

One unit of SGK1 = 1 nmol phosphate incorporated into crosstide substrate peptide in one minute.

forma física

Solution in 50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 0.1% β-mercaptoethanol, 0.15 M NaCl, 0.03% Brij^® L23, 1 mM benzamidine, 0.2 mM PMSF. and 270 mM sucrose.

Informações legais

Brij is a registered trademark of Croda International PLC

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids