RAB1320
Human Cathepsin Z ELISA
for serum, plasma and cell culture supernatants
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About This Item
reatividade de espécies
human
técnica(s)
ELISA: suitable
entrada
sample type serum
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... CTSZ(1522)
Descrição geral
Cathepsins are normally localized in lysosomes of almost all mammalian cells, but under certain conditions they can be secreted from the cells that take part in local proteolysis. Cathepsin Z is a cysteine protease, predominantly expressed in immune cells including monocytes, macrophages or dendritic cells.
This ELISA antibody pair detects Human Cathepsin Z (CTSZ/Cathepsin X/Cathepsin P)
Aplicação
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Ações bioquímicas/fisiológicas
Cathepsins are lysosomal proteases that play an important role in the intracellular degradation of exogenous and endogenous proteins, activation of enzyme precursors, and tumor invasion and metastasis. Cathepsin Z is known to be associated with the pathogenesis of cancer and promotes the development and proliferation of tumor cells. Cathepsin Z mediates the process of proliferation, migration, maturation, adhesion, signal transduction and phagocytosis of immune cells.
Outras notas
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Met. Corr. 1
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
European Journal of Cell Biology, 96(6), 622-631 (2017)
Localization and activity of various lysosomal proteases in Leishmania amazonensis-infected macrophages.
Infection and Immunity, 58(6), 1730-1737 (1990)
Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Pathology Research and Practice, 211(1), 62-70 (2015)
Cysteine cathepsins and the cutting edge of cancer invasion.
Cell Cycle, 6(1), 60-64 (2007)
The Journal of biological chemistry, 262(30), 14448-14453 (1987-10-25)
Negatively charged reactants are sensitive reactivity probes of the active site of cysteine proteases (Halász, P., and Polgár, L. (1977) Eur. J. Biochem. 79, 491-494). Thus, the thiolate-imidazolium ion pair of papain reacts at an enhanced rate with iodoacetate due
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