R5030

Ridaifen-B

≥98% (HPLC), white, solid

• Sinônimo(s): 1,1′-[(2-Phenyl-1-buten-1-ylidene)bis(4,1-phenyleneoxy-2,1-ethanediyl)]bis-pyrrolidine
• Fórmula empírica (Notação de Hill): C₃₄H₄₂N₂O₂
• Número CAS: 886465-70-9
• Peso molecular: 510.71
• Número MDL: MFCD11114395
• Código UNSPSC: 12352200
• ID de substância PubChem: 329824031
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: solid
• disponibilidade: not available in Japan
• condição de armazenamento: desiccated
• cor: white
• solubilidade: DMSO: ≥13 mg/mL; H₂O: insoluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CC\C(c1ccccc1)=C(/c2ccc(OCCN3CCCC3)cc2)c4ccc(OCCN5CCCC5)cc4
• InChI: 1S/C34H42N2O2/c1-2-33(28-10-4-3-5-11-28)34(29-12-16-31(17-13-29)37-26-24-35-20-6-7-21-35)30-14-18-32(19-15-30)38-27-25-36-22-8-9-23-36/h3-5,10-19H,2,6-9,20-27H2,1H3
• chave InChI: XQQWCGJGUHJSLR-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Ridaifen-B (RID-B) is a novel tamoxifen (TAM) analog that significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells.

Ridaifen-B (RID-B) is a novel tamoxifen (TAM) analog that significantly augments apoptosis-inducing effect of TAM in estrogen receptor (ER)-negatives cells. Ridaifen-B induces mitochondria-involved apoptosis in Jurkat cells, as evidenced by chromatin-condensed cells as well as downstream activation of caspases (caspase-3, -8 and -9) in a dose- and time-dependent manner. At 4 hours of incubation, IC50 for RID-B is 4 muM (30 muM for TAM). And at prolonged treatment of 48 hours, IC50 for RID-B is 0.1 muM. In a related report on the global anti-tumor activity, RID-B strongly inhibits 39 human cancer cells (JFCR 39), both ER-+ or ER-- at concentrations of equal or less than 1muM (e.g., at 0.38muM for SF-539 [central nervous system], at 0.58muM for HT-29 [colon], at 0.20muM for DMS114 [lung], at 0.21muM for LOX-IMVI [melanoma], and at 0.23muM for MKN74 [stomach]. The binding protein of RID-B that exerts the apoptosis events is currently under investigation.

Características e benefícios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H315,H318,H335
• Declarações de precaução: P280 - P302 + P352 - P305 + P351 + P338 + P310
• Classificações de perigo: Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves