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R137

Sigma-Aldrich

Ro 31-0432

solid

Sinônimo(s):

3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride, 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride, Bisindoylmaleimide XI

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About This Item

Fórmula empírica (Notação de Hill):
C28H28N4O2 · HCl
Número CAS:
145333-02-4
Peso molecular:
489.01
Código UNSPSC:
12352200
ID de substância PubChem:
329824001
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥98% (TLC)

forma

solid

condição de armazenamento

protect from light

cor

orange

solubilidade

DMSO: 5 mg/mL
H2O: insoluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H

chave InChI

HSPRASOZRZDELU-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.

Características e benefícios

This compound is featured on the GRKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Photosensitive

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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S E Wilkinson et al.
The Biochemical journal, 294 ( Pt 2), 335-337 (1993-09-01)
The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha
Soo Jung Lee et al.
International journal of molecular sciences, 20(24) (2019-12-11)
MicroRNAs (miRNAs) can be used to target a variety of human malignancy by targeting their oncogenes or tumor suppressor genes. The developmental endothelial locus-1 (Del-1) might be under miRNA regulation. This study investigated microRNA-137 (miR-137) function and Del-1 expression in
D Gozal et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(2), 641-648 (1998-02-26)
Although protein kinase C (PKC) is an essential component of multiple neurally mediated events, its role in respiratory control remains undefined. The ventilatory effects of a systemically active PKC inhibitor (Ro-32-0432; 100 mg/kg i.p.) were assessed by whole body plethysmography
Inhibition of PTH desensitization by inhibition of the G protein-coupled receptor kinase-5 enzyme with Ro 32-0432.
Moore, J.B., et al.
Faseb Journal, 12, A741-A741 (1998)
Yuchen Li et al.
Stem cell research & therapy, 11(1), 330-330 (2020-10-27)
We have previously verified the beneficial effects of exosomes from endothelial progenitor cells (EPC-EXs) in ischemic stroke. However, the effects of EPC-EXs in hemorrhagic stroke have not been investigated. Additionally, miR-137 is reported to regulate ferroptosis and to be involved
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