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Merck

P8624

Pirarubicin

≥95% (HPLC)

Sinônimo(s):

THP

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Sobre este item

Fórmula empírica (Notação de Hill):
C32H37NO12
Número CAS:
72496-41-4
Peso molecular:
627.64
Número MDL:
MFCD00869742
Código UNSPSC:
51281913
ID de substância PubChem:
329820330
NACRES:
NA.85

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Nível de qualidade

200

Ensaio

≥95% (HPLC)

Formulário

powder

solubilidade

ethanol: soluble 25 mg/mL

espectro de atividade do antibiótico

neoplastics

Modo de ação

DNA synthesis | interferes
enzyme | inhibits

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](OC6CCCCO6)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO

InChI

1S/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19-,21?,22-,31+,32-/m0/s1

chave InChI

KMSKQZKKOZQFFG-NCXNULAVSA-N

Aplicação

Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells[1][2]. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity[3].

Ações bioquímicas/fisiológicas

Pirarubicin, an anthracycline antibiotic that is an analog of doxorubicin, is an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter.1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.

Embalagem

10mg,25mg

Outras notas

Keep container tightly closed in a dry and well-ventilated place.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H340,H350,H360FD

Classificações de perigo

Carc. 1B - Muta. 1B - Repr. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
031M1149
031M1148
120M1529
100M1703
128K1628

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Akihiro Ito et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(11), 1422-1427 (2013-03-06)
We evaluated the efficacy of a single early intravesical instillation of pirarubicin (THP) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma (UUT-UC). From December 2005 to November 2008, 77 patients clinically diagnosed with UUT-UC
X X Wu et al.
Cancer research, 60(11), 2912-2918 (2000-06-13)
Anti-Fas monoclonal antibody (mAb) kills Fas-expressing cells by apoptosis. Several anticancer agents also mediate apoptosis and may share common intracellular pathways leading to apoptosis with Fas. Thus, we reasoned that combination treatment of drug-resistant cells with anti-Fas mAb and drugs
Y Mizutani et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 5(9), 2605-2612 (1999-09-28)
Resistance to conventional anticancer chemotherapeutic agents remains one of the major problems in the treatment of bladder cancer. Hence, new therapeutic modalities are necessary to treat the drug-resistant cancers. Apo-2 ligand (Apo-2L) is member of the tumor necrosis factor ligand
R Belhoussine et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(12), 1369-1376 (1998-11-17)
We used confocal microspectrofluorometry to investigate intracellular distribution of pirarubicin or THP-DOX in parental K562, CEM, and LR73 tumor cells and their corresponding multidrug-resistant (MDR) strains. Each spectrum of a recorded image was considered as a combination of cell autofluorescence
Matthieu Bourderioux et al.
Journal of proteome research, 14(1), 567-577 (2014-11-05)
Cystinuria is a purely renal, rare genetic disease caused by mutations in cystine transporter genes and characterized by defective cystine reabsorption leading to kidney stones. In 14% of cases, patients undergo nephrectomy, but given the difficulty to predict the evolution
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