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P0248

Sigma-Aldrich

PNU-37883A

≥98% (HPLC), powder

Sinônimo(s):

N-(1-Adamantyl)-N′-cyclohexyl-4-morpholinecarboxamidine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C21H36ClN3O
Número CAS:
57568-80-6
Peso molecular:
381.98
Número MDL:
MFCD06798347
Código UNSPSC:
12352200
ID de substância PubChem:
24277692

Ensaio

≥98% (HPLC)

forma

powder

cor

white

solubilidade

DMSO: ~23 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

Informações sobre genes

human ... KCNJ8(3764)

Ações bioquímicas/fisiológicas

Selective inhibitor of Kir6.1/SUR2B channels.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Salma Toma Hanna et al.
European journal of pharmacology, 515(1-3), 34-42 (2005-05-17)
Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human embryonic kidney (HEK-293) cells was
Noriyoshi Teramoto et al.
European journal of pharmacology, 506(1), 1-7 (2004-12-14)
Kinetic studies of U-37883A (4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl-hydrochloride), a vascular ATP-sensitive K+ channel (KATP channel) blocker, were performed on pig urethral myocytes to investigate inhibitory effects on large-conductance intracellular Ca2+ -sensitive K+ channels (i.e., BKCa channels; 225 pS K+ channels) by use of
Bo Jiang et al.
European journal of pharmacology, 577(1-3), 124-128 (2007-10-24)
Sulphonylureas, such as glybenclamide and gliclazide, are classical blockers of ATP-dependent potassium channels (K(ATP)). Closure of K(ATP) channels in vascular smooth muscles by sulphonylureas would lead to membrane depolarization and vasoconstriction but this hypothesis has not been consistently proved in
Julia Rivo et al.
Anesthesiology, 101(5), 1153-1159 (2004-10-27)
A3 adenosine receptor (AR) activation worsens or protects against renal and cardiac ischemia-reperfusion (IR) injury, respectively. The aims of the current study were to examine in an in vivo model the effect of A3AR activation on IR lung injury and
Yoshihiro Suzuki et al.
International journal of oncology, 41(2), 465-475 (2012-05-23)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is promising for cancer treatment owing to its selective cytotoxicity against malignant cells. However, some cancer cell types, including malignant melanoma cells, are resistant to TRAIL-induced apoptosis. Therefore, drugs that can amplify TRAIL cytotoxicity
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