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P0034

Sigma-Aldrich

20S-Protopanaxatriol

Sinônimo(s):

20(S)-APPT, g-PPT

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About This Item

Fórmula empírica (Notação de Hill):
C30H52O4
Número CAS:
34080-08-5
Peso molecular:
476.73
Número MDL:
MFCD11041271
Código UNSPSC:
12352200

forma

powder

Nível de qualidade

200

temperatura de armazenamento

2-8°C

InChI

1S/C30H52O4/c1-18(2)10-9-13-30(8,34)19-11-15-28(6)24(19)20(31)16-22-27(5)14-12-23(33)26(3,4)25(27)21(32)17-29(22,28)7/h10,19-25,31-34H,9,11-17H2,1-8H3/t19-,20+,21-,22+,23-,24-,25-,27+,28-,29+,30-/m0/s1

chave InChI

SHCBCKBYTHZQGZ-PHFGEWBZSA-N

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Descrição geral

A ginsenoside metabolite that has been linked to endothelial cell function via the glucocortoid receptor (GR) and the oestrogen receptor (ER).

Aplicação

20S-Protopanaxatriol (g-PPT), a dammarane-type tetracyclic terpene sapogenin, may be used to study its binding to and modulation of cell function via glucocortoid (GR) and oestrogen (ER) receptors.

Ações bioquímicas/fisiológicas

A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Yaping Ji et al.
Pain, 152(5), 1182-1191 (2011-03-12)
We previously reported that 17β-estradiol (E2) is pronociceptive in a visceral pain model in the rat. Subcutaneously (s.c.) administered E2 reversed the decrease in the colorectal distention (CRD)-evoked visceromotor response produced by ovariectomy (OVx) and CRD-induced nociceptive responses were greater
Jessica Santollo et al.
Physiology & behavior, 97(2), 193-198 (2009-03-04)
Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To
Kyu Lee Han et al.
Biological & pharmaceutical bulletin, 29(1), 110-113 (2006-01-06)
Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor of ligand-activated transcription factors, regulates the expression of key genes involved in lipid and glucose metabolism or adipocyte differentiation. Ligands for this receptor have emerged as potent insulin sensitizers
Hoi Hin Kwok et al.
Free radical biology & medicine, 48(3), 437-445 (2009-11-26)
Ginsenosides, the active components of the famous Chinese herb ginseng, have been suggested to possess cardiovascular-protective effects. The mechanism of ginsenosides is believed to be associated with their ability to prevent cellular oxidative stress. The purpose of this study was
Rui Liu et al.
Fitoterapia, 81(8), 1079-1087 (2010-07-16)
Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of
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