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Documentos Principais

O9505

Sigma-Aldrich

Orotidine

≥90% (HPLC)

Sinônimo(s):

Uridine-6-carboxylic acid

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About This Item

Fórmula empírica (Notação de Hill):
C10H12N2O8
Número CAS:
Peso molecular:
288.21
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:

Ensaio

≥90% (HPLC)

Formulário

powder

solubilidade

water: 50 mg/mL, clear, colorless to light yellow

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C(=O)NC(=O)C=C2C(O)=O

InChI

1S/C10H12N2O8/c13-2-4-6(15)7(16)8(20-4)12-3(9(17)18)1-5(14)11-10(12)19/h1,4,6-8,13,15-16H,2H2,(H,17,18)(H,11,14,19)/t4-,6-,7-,8-/m1/s1

chave InChI

FKCRAVPPBFWEJD-XVFCMESISA-N

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Aplicação

Orotidine, a nucleoside found naturally in fungi, bacteria and plants, may be used as a reference for the determination of presence of orotidine in urine or plasma due to urea cycle-related (transamidation) metabolic deficiencies or diseases.

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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H Horiuchi et al.
Life sciences, 66(21), 2051-2070 (2000-05-24)
We investigated the relationship between the toxic effect of allopurinol and pyrimidine metabolism in mice. Allopurinol-induced increases in plasma transaminase levels in dinitrofluorobenzene (DNFB)-sensitized mice were not affected by uridine. In contrast, plasma creatinine and BUN tended to decrease 18
A B Burlina et al.
Journal of inherited metabolic disease, 15(5), 707-712 (1992-01-01)
The allopurinol challenge test was performed on 44 healthy subjects (28 children and 16 adolescents) in order to establish normal values of urinary orotic acid excretion following allopurinol ingestion in the paediatric population. The subjects were divided into three groups
Elizabeth M Brown et al.
PloS one, 8(3), e59237-e59237 (2013-03-28)
Analysis of the population genetic structure of microbial species is of fundamental importance to many scientific disciplines because it can identify cryptic species, reveal reproductive mode, and elucidate processes that contribute to pathogen evolution. Here, we examined the population genetic
J A Arranz et al.
Clinical chemistry, 45(7), 995-1001 (1999-07-01)
The diagnosis of heterozygosity for X-linked ornithine carbamoyltransferase (OCT) deficiency has usually been based on measurement of the increase of orotate and orotidine excretion after an allopurinol load. We examined the choices of analyte, cutoff, and test conditions to obtain
H Nagasaka et al.
The Journal of pediatrics, 138(3), 432-434 (2001-03-10)
A liver transplantation from an asymptomatic mother, who was a carrier of ornithine transcarbamylase deficiency, to her daughter, who had severe manifestation, was successfully performed. One-year monitoring of plasma amino acid and urinary orotate/orotidine levels revealed no abnormality in the

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